Before
![Noticing Midlife Change?](/wp-content/uploads/2024/11/Middle-aged-caucasian-woman-after-ageing-skin-treatment.jpg" "Noticing Midlife Change?")
After
Noticing Midlife Change?
The skin begins to age at the age of 25, often disproportionately between the ages of 35 and 55, resulting in a dull complexion.
Yet 80% of it is preventable.
How It Works?
Renew ageing skin in 3 simple steps with Monderma:
Submit
Complete a free ingredient analysis
Start
Get your monthly ageing skin formula
Support
See progress—cancel, restart anytime
What's In Your Nightly Cream?
Delivered in a vegan base of hyaluronic acid and peptides, your personalised blend contains up to 3 dermatological actives, designed for optimal efficacy.
Recyclable
Vegan Friendly
Cruelty Free
Fragrance Free
Alcohol Free
GPhC Regulated Pharmacy
MHRA Approved Suppliers
Dermatologically Tested
Pharmacist Led
The Monderma Difference
| Retail | VS |  |
|---|---|---|
| Up To 3 Creams | All In One Multitasker | |
| Batch Produced | Personalised | |
| Over The Counter | Pharmacist Led | |
| Cosmetic Ingredients | Dermatological actives | |
| Lower Efficacy | Micronised | |
| Limited Strength | Up To 20x Strength | |
| Not Regulated | GPhC Regulated | |
| Self Assessment | MHRA Suppliers | |
Maximum Ageing Skin Results
Ageing skin formulas are supplied by GPhC registered prescribers and pharmacists for safe, effective use.
Individual results differ, but you will typically notice fewer fine lines and age spots. Mild side effects such as peeling, tingling, and redness may initially occur as your skin adjusts.
Tried, Tested, Loved: Hear It Firsthand
For the price point I really recommend them. Personable and thumbs up from me
“It definitely works as I can feel my skin feeling firmer and tighter, and have had a few people say my skin looks glowing!”
– Anand P, Middlesex, UK
I was expecting something this advanced to cost three times as much
“The fine wrinkles and sun damage are less noticeable, and my skin feels more youthful.”
– Julie T, Ceredigion, UK
Smooth fine lines, minimise wrinkles, and tone age spots decisively.
Get 50% off and enjoy free shipping with Monderma today—limited time only.
Still Have Questions?
Ageing skin starts around age 25 and accelerates in the 40's and 70's.
Women’s skin often intrinsically ages faster, while men are more affected by extrinsic factors.
Lighter skin tones tend to show wrinkles more visibly, while darker skin tones develop more hyperpigmentation.
Visible symptoms of ageing skin include fine lines and wrinkles, hyperpigmentation, thinning and loss of volume, and dry skin.
The face and neck show the most signs of ageing. It also affects the arms and legs more than other parts of the body.
Ageing skin occurs through dual mechanisms:
| Subtype | Description | Common Areas |
|---|---|---|
| Intrinsic Ageing (chronological) | Normal course of ageing, closely linked to the biological clock and the passage of time | Entire body |
| Extrinsic Ageing (photoageing) | Premature ageing caused by external factors, which accelerates intrinsic ageing | Face, neck, arms, and legs |
Up to 80% of ageing skin symptoms are attributed to extrinsic factors.
While intrinsic ageing cannot be prevented, reducing extrinsic ageing is becoming increasingly possible.
Ageing skin is caused by the skin’s decline in its ability to regenerate key structural molecules like collagen and elastin.
The causes of intrinsic ageing are:
| Cause | Description |
|---|---|
| Genetics | Genetics influence the rate at which cells replicate, repair, and respond to environmental stress. Mutations or variations in specific genes can accelerate cellular breakdown |
| Cellular | Cellular replication lasts about 50 cycles before genetic material can no longer be accurately copied. As senescent (ageing) cells accumulate and damage increases, the skin thins, loses elasticity, and become more fragile. Collagen, which gives skin structure and elasticity, declines by 1% each year after the age of 25. Elastin fibres, which help the skin return to its original shape after stretching, also diminish over time, making the skin looser and less resilient |
| Hormones | Hormones, particularly oestrogen and testosterone, decline with age, reducing skin elasticity and moisture, causing visible signs of ageing skin |
The extrinsic factors that accelerate ageing skin include:
| Contributor | Description |
|---|---|
| Photoageing | Photoageing, caused by UV (ultraviolet) radiation, particularly between 11am and 3pm, and the use of tanning beds, causes thousands of DNA alterations in skin cells every day. This accelerates the breakdown of collagen and elastin fibres |
| Nutrition | Nutrition, including diets high in sugar and processed foods can cause glycation, where these molecules bond with collagen. This, as well as a lack of hydration reduces flexibility |
| Medications | Medications, such as immunosuppressive agents, along with immune deficiency diseases and the psychological stress they treat, can accelerate cellular damage and diminish skin resilience |
| Smoking | Smoking, particularly nicotine, constricts blood vessels, reducing blood flow and limiting the oxygen and nutrients that reach skin cells |
| Alcohol | Alcohol, when consumed excessively, dehydrates and damages the skin, depleting it of essential moisture and nutrients |
| Skincare | Skincare becomes increasingly important as the natural exfoliation process slows down with age. Failure to cleanse properly can lead to a buildup of dead skin cells, oil, and dirt |
| Environment | Pollution, such as smoke, can clog pores and cause inflammation. Harsh working conditions and chronic stress can have an adverse effect on hormonal levels and skin health |
Understanding these extrinsic factors, especially sun exposure, is crucial for preventing premature ageing skin.
Monderma’s GPhC-registered prescribers can assess the extent of premature ageing through a visual assessment of uploaded images or a video consultation.
This entails examining exposed areas of the skin, such as your face and neck. To determine severity, symptoms and their characteristics are analysed.
To evaluate the duration and progression of your condition, Monderma's prescribers enquire about your medical history. This helps to determine potential causes and contributing factors.
The normal course of ageing includes:
| Age | Symptoms | Characteristics |
|---|---|---|
| 25-30 | Fine lines on the forehead and around the eyes | The skin begins to thin, reducing its barrier function and natural UV protection. Collagen mass and flexibility start depleting at a rate of about 1% per year |
| 30's | Fine lines on the cheeks, around the mouth, and on the neck, as well as mild hyperpigmentation | The skin's barrier function weakens, and cell metabolism slows. As hyaluronic acid production declines, skin moisture loss increases. Collagen continues to deplete at 1% per year, and the first effects of sun damage appear that occurred during the teenage years and 20's |
| 40's | Moderate wrinkles on the forehead, around the eyes, cheeks, mouth, and neck, increased dullness and dryness, and less volume in the cheeks and neck | The skin’s outer layers no longer lie in their proper order, resulting in a more pronounced dull appearance. Existing skin cells shrink, and fewer new cells are formed, leading to reduced skin volume |
| 50's | Thinner and less elastic skin and moderate hyperpigmentation | Connective tissues in the skin’s middle layer lose their fibrous structure and ability to retain water. Fat tissue in the lower layer thins |
| 60's | Deep wrinkles throughout the face, increased sagging, and significant dryness | The skin’s natural lipid production declines, as does the production of collagen and hyaluronic acid, resulting in deeper wrinkles and slower skin regeneration. The skin becomes more fragile and prone to dryness |
| Over 70 | Impaired wound healing and severe hyperpigmentation | The skin’s immune function weakens significantly, making it more vulnerable to infection. Wound healing slows, and hyperpigmentation becomes more severe due to prolonged exposure to environmental factors |
While ageing skin itself is a cosmetic concern, it can be a symptom of an underlying health issue that requires attention, such as nutritional deficiency or hormonal imbalance. This information is for informational purposes only. For specific concerns, please consult a healthcare professional.
If over-the-counter products have been ineffective or your skin is at risk of complications, Monderma may recommend a personalised treatment plan.
Each monthly ageing skin formula is carefully designed by Monderma’s GPhC-registered prescribers. They determine the optimal ingredients and strengths based on your free consultation.
Your treatment is further refined through ongoing feedback. This ensures it remains safe, effective, and tailored to your skin's unique needs.
This plan may contain up to 3 of the following dermatological ingredients:
| Ingredient | Properties |
|---|---|
| Retinoid | Speeds up skin cell renewal to shrink pores, clear spots, and smooth fine lines |
| Lightening Agent | Reduces melanin to lighten patches of darker skin |
| Anti-Inflammatory | Blocks irritable molecules to reduce redness, calm inflammation, and lighten patches of darker skin |
| Antioxidant | Strengthens the skin’s barrier function to lock in moisture and boost suppleness |
An ageing skin formula should be paired with daily application of a broad-spectrum sunscreen with SPF 30 or higher.
Visible results may start to be seen after 1 week, but lasting results typically take 8 weeks or longer. It is important to be patient and follow your treatment plan.
More information about each of Monderma's ingredients can be found in the information leaflet. This includes directions for use, safety information, storage, potential side effects, and reporting.
As the skin ages, cumulative damage from both intrinsic and extrinsic factors means it undergoes a series of changes that affect its appearance, texture, and function.
These visible changes include:
| Complication | Description |
|---|---|
| Fine Lines & Wrinkles | Dynamic wrinkles, such as frown lines, crow's feet, and laugh lines, are most noticeable when the muscles beneath them are active due to repeated facial movements. Static wrinkles, like forehead lines, cheek wrinkles, and marionette lines, are present even when the face is at rest. Gravitational wrinkles, typically jowls and neck wrinkles, appear in areas where the skin begins to sag as it loses elasticity with age. Atrophic wrinkles are fine lines that occur as a result of a decrease in the thickness and elasticity of the skin. Compression wrinkles, for example sleep lines, form due to external pressure on the face |
| Thinning & Fragility | Thinning skin becomes more fragile and vulnerable to injury, as both the middle (dermis) and outer (epidermis) layers lose their protective cushioning. This increases the likelihood of wounds, tears, and bruising, with slower healing due to impaired cell regeneration and a weakened vascular network, raising the risk of infection. Additionally, the loss of fat tissue beneath the skin leads to a noticeable reduction in volume, creating a hollowed appearance, particularly around the temples and cheeks |
| Dullness | Dull skin is usually the first symptom of ageing, as the skin's ability to shed dead cells and regenerate new ones slows down, leading to a buildup of dead cells on the surface and a lacklustre complexion. Reduced blood flow to the skin limits the delivery of oxygen and nutrients, further diminishing its natural vibrancy. Without the ability to reflect light effectively, ageing skin often appears matte and flat, making pores and pigmentation more noticeable |
| Dryness | Dry skin is common with ageing because the skin's ability to retain moisture and produce natural oils declines. As the skin ages, the sebaceous glands, which produce oil, become less active, resulting in a reduction in the protective lipid barrier that keeps the skin hydrated. Furthermore, the skin's natural ability to retain water decreases as hyaluronic acid production slows, resulting in moisture loss from the skin's deeper layers. This results in a rough, flaky texture that can be itchy and irritating |
| Hyperpigmentation | Hyperpigmentation in ageing skin is often driven by slower cell turnover, hormonal changes, inflammation, and cumulative sun damage. As the skin’s ability to renew itself declines with age, dark spots and uneven pigmentation become more prominent |
| Rosacea | Rosacea becomes more likely as the skin ages, with blood vessels becoming more visible near the surface, making them more susceptible to dilation and damage. Additionally, the skin’s diminished ability to repair itself and control inflammation increases the risk of developing rosacea or exacerbating redness and sensitivity |
| Psychosocial | Psychosocial factors related to early physical changes in appearance and societal attitudes associated with ageing can have an impact on self-esteem, particularly in the 30's and 40's |
Understanding and managing these complications is important for maintaining healthier, more resilient skin and promoting overall wellbeing as one ages.