Ageing Skin

Ageing skin is a gradual process that starts around age 25 and accelerates in the 40’s and again in the 70’s.

Women’s skin intrinsically ages faster than men’s, but men are often more affected by extrinsic factors such as lifestyle.

Lighter skin tones tend to show wrinkles more visibly, while darker skin tones develop more hyperpigmentation.

The visible symptoms of ageing skin include fine lines and wrinkles, hyperpigmentation, thinning and loss of volume, and dry skin.

The face and neck are most impacted by ageing. It also affects the arms and legs more than other parts of the body.

Ageing skin occurs through two mechanisms:

Subtype	Description	Common Areas
Intrinsic (chronological)	Normal course of ageing, closely linked to the biological clock and the passage of time	Entire body
Extrinsic (photoageing)	Premature ageing caused by external factors, which accelerates intrinsic ageing	Face, neck, arms, and legs

Up to 80% of ageing skin symptoms are attributed to extrinsic factors.

While intrinsic ageing cannot be prevented, reducing extrinsic ageing has become increasingly possible.

Ageing skin is caused by a loss of the skin's ability to regenerate collagen and elastin, two essential molecules that give it its strength and mobility.

Collagen is a protein that provides structure and elasticity to the skin. After the age of 20, production declines by about 1% per year.

Elastin fibres help the skin to return to its original shape after stretching. As elastin depletes, the skin can become more lax and less resilient.

The primary causes of intrinsic ageing are the following:

Cause	Description
Genetics	Genetics can influence the rate at which the body ages by determining how cells replicate, repair, and respond to environmental stress. Mutations or variations in specific genes can cause faster cellular breakdown, resulting in premature signs of ageing, notably wrinkles
Cellular	Cellular replication is limited to about 50 cycles before the genetic material can no longer be accurately copied. As senescent cells accumulate and damage worsens, the skin thins, loses its elasticity, and becomes more fragile
Hormones	Hormones, particularly oestrogen and testosterone, decline with age, reducing skin elasticity and moisture. This hormonal shift contributes to visible signs of ageing, such as wrinkles and dryness

The extrinsic factors that accelerate ageing include:

Contributor	Description
Photoageing	Photoageing, caused by UV (ultraviolet) radiation, particularly between 11am and 3pm, as well as the use of tanning beds, causes thousands of DNA alterations in each cell of the skin every day. This accelerates the breakdown of collagen and elastin fibres, leading to wrinkles, rough skin texture, and age spots and patches
Nutrition	Nutrition, including diets high in sugar and processed foods, can cause glycation, where sugar molecules bond with proteins like collagen, reducing their flexibility. Antioxidant-rich foods, such as fruits and vegetables, can help to combat oxidative stress. Lack of hydration can harm the skin's health and appearance, increasing the risk of premature wrinkles and thinning
Medications	Medications, such as immunosuppressive agents, along with immune deficiency diseases and the psychological stress they treat, can accelerate cellular damage and reduced skin resilience
Smoking	Smoking, particularly due to nicotine, narrows blood vessels and reduces blood flow, limiting the amount of oxygen and nutrients that reach skin cells. This leads to a sallow complexion and accelerates skin ageing
Alcohol	Alcohol, when consumed excessively, dehydrates and damages the skin, diminishing its natural glow. This results in dryness, wrinkles, and a dull complexion over time
Skincare	Skincare becomes increasingly important as the natural exfoliation process slows with age. Not cleansing properly can cause a buildup of dead skin cells, oil, and dirt, resulting in a dull complexion
Environment	Pollution, such as particulate matter and smoke, can clog pores, cause inflammation, and leave the skin looking dull. Harsh working conditions and chronic stress can have an adverse effect on hormonal levels and skin health

Understanding these extrinsic factors, particularly sun exposure, is key to manage and mitigate premature ageing and a tired, lacklustre appearance.

A doctor, pharmacist, or nurse can determine the extent of premature ageing. This involves examining exposed areas of the skin to assess its underlying causes.

The normal course of ageing includes:

Age	Symptoms	Description
25-30	Fine lines on the forehead and around the eyes	The skin begins to thin, reducing its barrier function and natural UV protection. Collagen mass and flexibility start depleting at a rate of about 1% per year
30's	Fine lines on the cheeks, around the mouth, and on the neck, as well as mild hyperpigmentation	The skin's barrier function weakens, and cell metabolism slows. As hyaluronic acid production declines, skin moisture loss increases. Collagen continues to deplete at 1% per year, and the first effects of sun damage appear that occurred during the teenage years and 20's
40's	Moderate wrinkles on the forehead, around the eyes, cheeks, mouth, and neck, increased dullness and dryness, and less volume in the cheeks and neck	The skin’s outer layers no longer lie in their proper order, resulting in a more pronounced dull appearance. Existing skin cells shrink, and fewer new cells are formed, leading to reduced skin volume
50's	Thinner and less elastic skin and moderate hyperpigmentation	Connective tissues in the skin’s middle layer lose their fibrous structure and ability to retain water. Fat tissue in the lower layer thins
60's	Deep wrinkles throughout the face, increased sagging, and significant dryness	The skin’s natural lipid production declines, as does the production of collagen and hyaluronic acid, resulting in deeper wrinkles and slower skin regeneration. The skin becomes more fragile and prone to dryness
Over 70	Impaired wound healing and severe hyperpigmentation	The skin’s immune function weakens significantly, making it more vulnerable to infection. Wound healing slows, and hyperpigmentation becomes more severe due to prolonged exposure to environmental factors

While ageing skin itself is a cosmetic concern, it can be a symptom of an underlying health issue that requires attention, such as nutritional deficiency or hormonal imbalance. This information is for informational purposes only. For specific concerns, please consult a healthcare professional.

If the skin has not responded to over-the-counter products or is at risk of complications, Monderma may recommend a treatment plan.

This may contain up to 3 of the following ingredients:

Topical	Properties
Retinoids	Regulate the growth of cells on the skin to improve its texture and tone
Lightening Agents	Reduce the production of melanin to lighten patches of darker skin
Anti-Inflammatories	Inhibit the production of inflammatory-causing molecules to reduce redness and irritation
Antioxidants	Eliminate free radicals by repairing and strengthening the barrier function of the skin, improving hydration

Treating ageing skin topically must include adopting daily use of broad-spectrum sunscreen of SPF30 or higher.

It can take 8 weeks or longer to see lasting results, so it is important to be patient and follow your treatment plan.

Information on these ingredients, their directions for use, safety information, storage, potential side effects, and reporting can be found in the information leaflet

As the skin ages, cumulative damage from both intrinsic and extrinsic factors means it undergoes a series of changes that affect its appearance, texture, and function.

These visible changes include:

Complication	Description
Fine Lines & Wrinkles	Dynamic wrinkles, such as frown lines, crow's feet, and laugh lines, are most noticeable when the muscles beneath them are active due to repeated facial movements. Static wrinkles, like forehead lines, cheek wrinkles, and marionette lines, are present even when the face is at rest. Gravitational wrinkles, typically jowls and neck wrinkles, appear in areas where the skin begins to sag as it loses elasticity with age. Atrophic wrinkles are fine lines that occur as a result of a decrease in the thickness and elasticity of the skin. Compression wrinkles, for example sleep lines, form due to external pressure on the face
Thinning & Fragility	Thinning skin becomes more fragile and vulnerable to injury, as both the middle (dermis) and outer (epidermis) layers lose their protective cushioning. This increases the likelihood of wounds, tears, and bruising, with slower healing due to impaired cell regeneration and a weakened vascular network, raising the risk of infection. Additionally, the loss of fat tissue beneath the skin leads to a noticeable reduction in volume, creating a hollowed appearance, particularly around the temples and cheeks
Dullness	Dull skin is usually the first symptom of ageing, as the skin's ability to shed dead cells and regenerate new ones slows down, leading to a buildup of dead cells on the surface and a lacklustre complexion. Reduced blood flow to the skin limits the delivery of oxygen and nutrients, further diminishing its natural vibrancy. Without the ability to reflect light effectively, ageing skin often appears matte and flat, making pores and pigmentation more noticeable
Dryness	Dry skin is common with ageing because the skin's ability to retain moisture and produce natural oils declines. As the skin ages, the sebaceous glands, which produce oil, become less active, resulting in a reduction in the protective lipid barrier that keeps the skin hydrated. Furthermore, the skin's natural ability to retain water decreases as hyaluronic acid production slows, resulting in moisture loss from the skin's deeper layers. This results in a rough, flaky texture that can be itchy and irritating
Hyperpigmentation	Hyperpigmentation in ageing skin is often driven by slower cell turnover, hormonal changes, inflammation, and cumulative sun damage. As the skin’s ability to renew itself declines with age, dark spots and uneven pigmentation become more prominent
Rosacea	Rosacea becomes more likely as the skin ages, with blood vessels becoming more visible near the surface, making them more susceptible to dilation and damage. Additionally, the skin’s diminished ability to repair itself and control inflammation increases the risk of developing rosacea or exacerbating redness and sensitivity
Psychosocial	Psychosocial factors related to early physical changes in appearance and societal attitudes associated with ageing can have an impact on self-esteem, particularly in the 30's and 40's

Understanding and managing these complications is important for maintaining healthier, more resilient skin and promoting overall wellbeing as one ages.